Mitigation of evolved bacterial resistance to phage therapy

Current Opinion in Virology
Year of Publication: 
Torres-Barceló C, Turner PE, Buckling A
The ease with which bacteria can evolve resistance to phages is a key consideration for development of phage therapy. Here, we review recent work on the different evolutionary and ecological approaches to mitigate the problem. The approaches are broadly categorised into two areas: Minimising evolved phage resistance; and Directing phage-resistance evolution towards therapeutically beneficial outcomes.