Phage Therapy and Phage-Bacteria Interactions in the Evolution of Antibiotic Resistance

The rise of antibiotic resistance in bacterial pathogens presents an increasing challenge in public health and in agricultural systems. Phage therapy (use of phages to combat bacterial infections) may provide a viable alternative, when phage alone or in combination with traditional antibiotics are used to target multi-drug resistant bacteria. We examine how phage exert selection pressure on pathogenic bacteria, especially phage binding to virulence factors that selects for bacteria to evolve reduced virulence. These studies are wide-ranging, using mathematical models, in vitro selection experiments, and animal models, and even involve emergency treatment in humans.


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